Episode 55 Rocky Mountain spotted fever: The tick must be destroyed!

Despite what its name might suggest, the story of Rocky Mountain spotted fever (RMSF) takes us far beyond the jagged, snow-capped peaks of the western range. From the Bitterroot Valley to southeastern Brazil, it is a story filled with equal parts tragedy and discovery, as the researchers desperate for answers fall victim to the very disease they seek to prevent. In this episode, we dive into the dark past of this deadly disease, first exploring the biology of the teeny tiny organism that wreaks such devastation. As always, we follow that up by tracing the history surrounding this much-feared infection and its role in the creation of one of the world’s leading infectious disease laboratories. Finally, we end with the current status of RMSF, which (spoilers) isn’t as bleak as you might think, thanks once again to antibiotics. Tune in to hear why we’ve been excited to research this episode since the very beginning of the podcast.

HistoryBiology
Harden, Victoria Angela. Rocky Mountain spotted fever. History of a twentieth-century disease. Johns Hopkins University Press, 1990.Dantas-Torres, Filipe. “Rocky Mountain spotted fever.The Lancet infectious diseases 7.11 (2007): 724-732.
Álvarez-Hernández, Gerardo, et al. “Rocky Mountain spotted fever in Mexico: past, present, and future.” The Lancet Infectious Diseases 17.6 (2017): e189-e196.Helmick, Charles G., Kenneth W. Bernard, and Lawrence J. D’Angelo. “Rocky Mountain spotted fever: clinical, laboratory, and epidemiological features of 262 cases.” Journal of Infectious Diseases 150.4 (1984): 480-488.
Tigertt, William D. “A 1759 spotted fever epidemic in North Carolina.” Journal of the history of medicine and allied sciences 42.3 (1987): 296-304.Walker D.H., Blanton L.S. “Chapter 188: Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers)” (2014)  Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases,  2 , pp. 2198-2205.
Chen, Luke F., and Daniel J. Sexton. “What’s new in Rocky Mountain spotted fever?.” Infectious disease clinics of North America 22.3 (2008): 415-432.
CDC. “Rocky mountain spotted fever: epidemiology and statistics” updated April 7 2020. https://www.cdc.gov/rmsf/stats/index.html
McClain, Micah T., and Daniel J. Sexton. “Surveillance for spotted fever group rickettsial infections: Problems, pitfalls, and potential solutions.” (2020): 1238-1240.
Álvarez-Hernández, Gerardo, et al. “Rocky Mountain spotted fever in Mexico: past, present, and future.” The Lancet Infectious Diseases 17.6 (2017): e189-e196.
Alhassan, Andy, et al. “Rickettsia rickettsii whole-cell antigens offer protection against Rocky Mountain spotted fever in the canine host.” Infection and immunity 87.2 (2019).

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