For the entirety of our species’ history, our approach to cancer has largely been to react, to design new therapies and better combinations of treatments. This energy has certainly been well-spent, but what if we didn’t have to use treatment at all? Or what if we could minimize the use of aggressive therapies? Prevention and screening represent two under-appreciated pillars of cancer care, and we’re using this final installment in our cancer miniseries to show some appreciation. To grasp the impact that screening and prevention can have, we also need to consider the global landscape of cancer prevalence and incidence – where is it decreasing? Where is it on the rise? Where can intervention or prevention make an impact? As we’ve shown over these four episodes, science and medicine has accumulated a wealth of information about cancer – but the striking racial and socioeconomic disparities in cancer incidence and mortality in the US and around the world demonstrates that that knowledge has not been applied equally. Any proposal to reduce the global cancer burden must address the systemic issues driving these disparities. Tune in for a thought-provoking reflection on the status of cancer today.
| History | Biology |
| Mukherjee, Siddhartha. The emperor of all maladies: a biography of cancer. Simon and Schuster, 2010. | Sherman, R.L., Firth, A.U., Henley, S.J., Siegel, R.L., Negoita, S., Sung, H., Kohler, B.A., Anderson, R.N., Cucinelli, J., Scott, S. and Benard, V.B., 2025. Annual Report to the Nation on the Status of Cancer, featuring state‐level statistics after the onset of the COVID‐19 pandemic. Cancer, 131(9), p.e35833. |
| Ahmad, Amar S., Nick Ormiston-Smith, and Peter D. Sasieni. “Trends in the lifetime risk of developing cancer in Great Britain: comparison of risk for those born from 1930 to 1960.” British journal of cancer 112.5 (2015): 943-947. | Islami, F., Arias, G., Lee, D., Wiese, D., Baeker Bispo, J., Yabroff, K.R., Siegel, R.L., Bandi, P., Nargis, N., Patel, A.V. and Thienprayoon, P.P., 2026. American Cancer Society’s Report on the Status of Cancer Disparities in the United States, 2025. CA: A Cancer Journal for Clinicians, 76(1), p.e70045. |
| American Cancer Society. Cancer Facts and Figures 2025. Atlanta: American Cancer Society; 2025. | Force, L.M., Kocarnik, J.M., May, M.L., Bhangdia, K., Crist, A., Penberthy, L., Pritchett, N., Acheson, A., Deitesfeld, L., Aalruz, H. and Abbas, N., 2025. The global, regional, and national burden of cancer, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023. The Lancet, 406(10512), pp.1565-1586. |
| Bailar, John C., and Heather L. Gornik. “Cancer undefeated.” New England Journal of Medicine 336.22 (1997): 1569-1574. | Tran, K.B., Lang, J.J., Compton, K., Xu, R., Acheson, A.R., Henrikson, H.J., Kocarnik, J.M., Penberthy, L., Aali, A., Abbas, Q. and Abbasi, B., 2022. The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 400(10352), pp.563-591. |
| Faguet, Guy B. “A brief history of cancer: age‐old milestones underlying our current knowledge database.” International journal of cancer 136.9 (2015): 2022-2036. | Bauer, C., Zhang, K., Xiao, Q., Lu, J., Hong, Y.R. and Suk, R., 2022. County-level social vulnerability and breast, cervical, and colorectal cancer screening rates in the US, 2018. JAMA Network Open, 5(9), pp.e2233429-e2233429. |
| Hajdu, Steven I. “Pathfinders in oncology from ancient times to the end of the Middle Ages.” Cancer 122.11 (2016): 1638-1646. | NCI Surveillence, Epidemiology and End Results (SEER) program. https://seer.cancer.gov/statistics-network/explorer/application.html?site=1&data_type=1&graph_type=2&compareBy=sex&chk_sex_3=3&chk_sex_2=2&rate_type=2&race=1&age_range=1&hdn_stage=101&advopt_precision=1&advopt_show_ci=on#resultsRegion0 |
| Hajdu, Steven I. “A note from history: landmarks in history of cancer, part 3.” Cancer 118.4 (2012): 1155-1168. | https://nccrexplorer.ccdi.cancer.gov/ |
| Hajdu, Steven I. “A note from history: landmarks in history of cancer, part 4.” Cancer 118.20 (2012): 4914-4928. | NCI Surveillence, Epidemiology and End Results (SEER) program. Cancer Stat Facts: https://seer.cancer.gov/statfacts/ |
| Hajdu, Steven I., and Farbod Darvishian. “A note from history: landmarks in history of cancer, part 5.” Cancer 119.8 (2013): 1450-1466. | Global Cancer Observatory: https://gco.iarc.fr/en |
| Hajdu, Steven I., and Manjunath Vadmal. “A note from history: Landmarks in history of cancer, Part 6.” Cancer 119.23 (2013): 4058-4082. | Duffy, S.W. and Offman, J., 2026. A guide to cancer screening. Nature Reviews Clinical Oncology, pp.1-12. |
| Hajdu, Steven I., Manjunath Vadmal, and Ping Tang. “A note from history: Landmarks in history of cancer, part 7.” Cancer 121.15 (2015): 2480-2513. | Agbedinu, K., Antwi, S., Aduse-Poku, L., Akakpo, P.K., Larrious-Lartey, H., Ofori Aboah, V., Mensah, S., Nyarko, V., Amponsah-Manu, F., Nsaful, J. and Dampson, R., 2025. A Scoping Review on Barriers to Cancer Diagnosis and Care in Low-and Middle-Income Countries. Cancer Epidemiology, Biomarkers & Prevention, 34(7), pp.1066-1073. |
| Smedley, Brian D., and M. Alfred Haynes, eds. “The unequal burden of cancer: an assessment of NIH research and programs for ethnic minorities and the medically underserved.” (1999). | Wan, J.C., Sasieni, P. and Rosenfeld, N., 2025. Promises and pitfalls of multi-cancer early detection using liquid biopsy tests. Nature Reviews Clinical Oncology, pp.1-15. |
| American Cancer Society, Known and Probable Human Carcinogens. August 1, 2024. Accessed Jan 16, 2026. | Chung, D.C., Gray, D.M., Singh, H., Issaka, R.B., Raymond, V.M., Eagle, C., Hu, S., Chudova, D.I., Talasaz, A., Greenson, J.K. and Sinicrope, F.A., 2024. A cell-free DNA blood-based test for colorectal cancer screening. New England Journal of Medicine, 390(11), pp.973-983. |
| Andermann, Anne, et al. “Revisiting Wilson and Jungner in the genomic age: a review of screening criteria over the past 40 years.” Bulletin of the World Health Organization 86.4 (2008): 317-319. | Bleyer, A., Barr, R., Hayes-Lattin, B., Thomas, D., Ellis, C., Anderson, B. and Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adult Oncology, 2008. The distinctive biology of cancer in adolescents and young adults. Nature Reviews Cancer, 8(4), pp.288-298. |
| Benmoussa, Nadia, et al. “Chimney-sweeps’ cancer—early proof of environmentally driven tumourigenicity.” The Lancet Oncology 20.3 (2019): 338. | Boucai, L., Zafereo, M. and Cabanillas, M.E., 2024. Thyroid cancer: a review. Jama, 331(5), pp.425-435. |
| Bode, Ann M., and Zigang Dong. “Cancer prevention research—then and now.” Nature Reviews Cancer 9.7 (2009): 508-516. | Caruso, G., Weroha, S.J. and Cliby, W., 2025. Ovarian cancer: a review. Jama. |
| Brown, John R., and John L. Thornton. “Percivall Pott (1714-1788) and chimney sweepers’ cancer of the scrotum.” British journal of industrial medicine 14.1 (1957): 68. | Perkins, R.B., Wentzensen, N., Guido, R.S. and Schiffman, M., 2023. Cervical cancer screening: a review. Jama, 330(6), pp.547-558. |
| Cairns, John. “The treatment of diseases and the war against cancer.” Scientific American 253.5 (1985): 51-59. | Waks, A.G. and Winer, E.P., 2019. Breast cancer treatment: a review. Jama, 321(3), pp.288-300. |
| Croswell, Jennifer M., David F. Ransohoff, and Barnett S. Kramer. “Principles of cancer screening: lessons from history and study design issues.” Seminars in oncology. Vol. 37. No. 3. WB Saunders, 2010. | Biller, L.H. and Schrag, D., 2021. Diagnosis and treatment of metastatic colorectal cancer: a review. Jama, 325(7), pp.669-685. |
| Doll, Richard, and A. Bradford Hill. “Lung cancer and other causes of death in relation to smoking.” British medical journal 2.5001 (1956): 1071. | Koh, B., Tan, D.J.H., Ng, C.H., Fu, C.E., Lim, W.H., Zeng, R.W., Yong, J.N., Koh, J.H., Syn, N., Meng, W. and Wijarnpreecha, K., 2023. Patterns in cancer incidence among people younger than 50 years in the US, 2010 to 2019. JAMA network open, 6(8), pp.e2328171-e2328171. |
| Doll, Sir Richard. “The epidemiology of cancer.” Cancer 45.10 (1980): 2475-2485. | Brennan, P. and Davey-Smith, G., 2022. Identifying novel causes of cancers to enhance cancer prevention: new strategies are needed. JNCI: Journal of the National Cancer Institute, 114(3), pp.353-360. |
| Fisher, Ronald. “Cigarettes, cancer, and statistics.” The Centennial Review of Arts & Science 2 (1958): 151-166. | White, A., Ironmonger, L., Steele, R.J., Ormiston-Smith, N., Crawford, C. and Seims, A., 2018. A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK. BMC cancer, 18(1), p.906. |
| Garfinkel, Lawrence. “Trends in cigarette smoking in the United States.” Preventive medicine 26.4 (1997): 447-450. | Schlossberg. Nov 2025. A battle with my blood. The New Yorker. https://www.newyorker.com/culture/the-weekend-essay/a-battle-with-my-blood |
| Gold, Richard H., Lawrence W. Bassett, and Bobbi E. Widoff. “Highlights from the history of mammography.” Radiographics 10.6 (1990): 1111-1131. | Sung, H., Siegel, R.L., Rosenberg, P.S. and Jemal, A., 2019. Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry. The Lancet Public Health, 4(3), pp.e137-e147. |
| Greenwald, Peter, and Barbara K. Dunn. “Landmarks in the history of cancer epidemiology.” Cancer research 69.6 (2009): 2151-2162. | |
| Islami, Farhad, et al. “American Cancer Society’s Report on the Status of Cancer Disparities in the United States, 2025.” CA: A Cancer Journal for Clinicians 76.1 (2026): e70045. | |
| Islami, Farhad, et al. “American Cancer Society’s report on the status of cancer disparities in the United States, 2021.” CA: a cancer journal for clinicians 72.2 (2022): 112-143. | |
| Jeon, Jihyoun, et al. “Smoking and lung cancer mortality in the United States from 2015 to 2065: a comparative modeling approach.” Annals of internal medicine 169.10 (2018): 684-693. | |
| Kipling, M. D., and H. A. Waldron. “Percivall Pott and cancer scroti.” British journal of industrial medicine 32.3 (1975): 244. | |
| Linet, Martha S. “Evolution of cancer epidemiology.” Epidemiologic reviews 22.1 (2000): 35-56. | |
| Mattiuzzi, Camilla, and Giuseppe Lippi. “Current cancer epidemiology.” Journal of epidemiology and global health 9.4 (2019): 217-222. | |
| Proctor, Robert N. “The history of the discovery of the cigarette–lung cancer link: evidentiary traditions, corporate denial, global toll.” Tobacco control 21.2 (2012): 87-91. | |
| Schwartz, Stephen M. “Epidemiology of cancer.” Clinical chemistry 70.1 (2024): 140-149. | |
| Schottenfeld, David. “The epidemiology of cancer: an overview.” Cancer 47.S5 (1981): 1095-1108. | |
| Sharma, Divakar, Thomas G. Newman, and Wilbert Aronow. “Lung cancer screening: history, current perspectives, and future directions.” Archives of Medical Science 11.5 (2015): 1033-1043. | |
| Swanson, Amy A., and Liron Pantanowitz. “The evolution of cervical cancer screening.” Journal of the American Society of Cytopathology 13.1 (2024): 10-15. | |
| Vilos, George A. “The history of the Papanicolaou smear and the odyssey of George and Andromache Papanicolaou.” Obstetrics & Gynecology 91.3 (1998): 479-483. | |
| Winawer, Sidney J. “The history of colorectal cancer screening: a personal perspective.” Digestive diseases and sciences 60.3 (2015): 596-608. | |
| Wong, Yide, et al. “Estimating the global burden of Epstein–Barr virus-related cancers.” Journal of Cancer Research and Clinical Oncology 148.1 (2022): 31-46. |
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