CW: discussion of disordered eating, eating disorders
Did the word gluten manifest in everyone’s consciousness one day in 2010? Suddenly, grocery stores were filled with gluten-free crackers, cookies, buns, you name it. Everyone went on gluten-free diets or knew someone with a gluten intolerance or sensitivity. For some, it might seem that gluten-related disorders went from 0 to 60 overnight, but those who had lived with these illnesses for decades knew better. In this episode, we delve into the story of gluten intolerance and celiac disease, a story which begins thousands of years ago, not just in the 2010s. We break down why gluten makes some people sick, how scientists finally made the link between grain and pain, and what promising new research is on the horizon for treating gluten-related disorders. Tune in today!
| History | Biology |
| Anderson, Warwick H., and Ian R. Mackay. “Gut Reactions—From Celiac Affection to Autoimmune Model.” New England Journal of Medicine 371.1 (2014): 6-7. | Rubio-Tapia, A., Hill, I.D., Semrad, C., Kelly, C.P., Greer, K.B., Limketkai, B.N. and Lebwohl, B., 2023. American College of Gastroenterology guidelines update: diagnosis and management of celiac disease. Official journal of the American College of Gastroenterology| ACG, 118(1), pp.59-76. |
| Burki, Talha Khan. “Samuel Gee: the modern era for coeliac disease.” The Lancet Gastroenterology & Hepatology 4.2 (2019): 100. | Rubin, J.E. and Crowe, S.E., 2020. Celiac disease. Annals of internal medicine, 172(1), pp.ITC1-ITC16. |
| Caio, Giacomo, et al. “Celiac disease: a comprehensive current review.” BMC medicine 17 (2019): 1-20. | Iversen, R. and Sollid, L.M., 2023. The immunobiology and pathogenesis of celiac disease. Annual Review of Pathology: Mechanisms of Disease, 18, pp.47-70. |
| CARTER, CEDRIC, WILFRID SHELDON, and COLIN WALKER. “The inheritance of coeliac disease.” Annals of Human Genetics 23.3 (1959): 266-278. | Rubio-Tapia, A., Rahim, M.W., See, J.A., Lahr, B.D., Wu, T.T. and Murray, J.A., 2010. Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet. Official journal of the American College of Gastroenterology| ACG, 105(6), pp.1412-1420. |
| Cenit, María Carmen, et al. “Intestinal microbiota and celiac disease: cause, consequence or co-evolution?.” Nutrients 7.8 (2015): 6900-6923. | Lebwohl, B. and Rubio-Tapia, A., 2021. Epidemiology, presentation, and diagnosis of celiac disease. Gastroenterology, 160(1), pp.63-75. |
| Dowd, Bryan, and John Walker-Smith. “Samuel Gee, Aretaeus, and the coeliac affection.” British medical journal 2.5909 (1974): 45. | Kemppainen, K.M., Lynch, K.F., Liu, E., Lönnrot, M., Simell, V., Briese, T., Koletzko, S., Hagopian, W., Rewers, M., She, J.X. and Simell, O., 2017. Factors that increase risk of celiac disease autoimmunity after a gastrointestinal infection in early life. Clinical gastroenterology and hepatology, 15(5), pp.694-702. |
| Ebbs, J. H. “Coeliac disease.” Canadian Medical Association Journal 75.11 (1956): 885. | Taraghikhah, N., Ashtari, S., Asri, N., Shahbazkhani, B., Al-Dulaimi, D., Rostami-Nejad, M., Rezaei-Tavirani, M., Razzaghi, M.R. and Zali, M.R., 2020. An updated overview of spectrum of gluten-related disorders: clinical and diagnostic aspects. BMC gastroenterology, 20, pp.1-12. |
| Gasbarrini, Giovanni, et al. “When was celiac disease born?: the Italian case from the archeologic site of Cosa.” Journal of clinical gastroenterology 44.7 (2010): 502-503. | Alkalay, M.J., 2020. Update on celiac disease. Current opinion in pediatrics, 32(5), pp.654-660. |
| Gasbarrini, Giovanni Battista, et al. “Coeliac disease: an old or a new disease? History of a pathology.” Internal and emergency medicine 9 (2014): 249-256. | King, J.A., Jeong, J., Underwood, F.E., Quan, J., Panaccione, N., Windsor, J.W., Coward, S., Debruyn, J., Ronksley, P.E., Shaheen, A.A. and Quan, H., 2020. Incidence of celiac disease is increasing over time: a systematic review and meta-analysis. Official journal of the American College of Gastroenterology| ACG, 115(4), pp.507-525. |
| Gee, S. “On the coeliac affection.”St Barth Hosp Rep 24 (1888): 17-20. | Dieckman, T., Koning, F. and Bouma, G., 2022. Celiac disease: New therapies on the horizon. Current opinion in pharmacology, 66, p.102268. |
| Gibbons, Robert Alexander. “The coeliac affection in children.” Edinburgh Medical Journal 35.4 (1889): 321. | |
| Kerner, Gaspard, et al. “Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe.” Cell genomics 3.2 (2023). | |
| Losowsky, Monty S. “A history of coeliac disease.” Digestive diseases 26.2 (2008): 112-120. | |
| Newberry, Carolyn, et al. “Going gluten free: the history and nutritional implications of today’s most popular diet.” Current gastroenterology reports 19 (2017): 1-8. | |
| Paveley, William F. “From Aretaeus to Crosby: a history of coeliac disease.” BMJ: British Medical Journal 297.6664 (1988): 1646. | |
| Reilly, Norelle R. “The gluten-free diet: recognizing fact, fiction, and fad.” The Journal of pediatrics 175 (2016): 206-210. | |
| Rostami, Kamran, et al. “Coeliac disease in Middle Eastern countries: a challenge for the evolutionary history of this complex disorder?.” Digestive and liver disease 36.10 (2004): 694-697. | |
| RUHRÄH, JOHN. “SAMUEL GEE 1839-1911: A NOTE ON THE HISTORY OF CELIAC DISEASE.” American Journal of Diseases of Children 48.1 (1934): 159-164. | |
| Sams, Aaron, and John Hawks. “Patterns of population differentiation and natural selection on the celiac disease background risk network.” PLoS One 8.7 (2013): e70564. | |
| Sams, Aaron, and John Hawks. “Celiac disease as a model for the evolution of multifactorial disease in humans.” Human Biology 86.1 (2014): 19-36. | |
| Zhernakova, Alexandra, et al. “Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection.” The American Journal of Human Genetics 86.6 (2010): 970-977. |
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4 thoughts on “Episode 146 Celiac Disease: Rootin tootin gluten”
Hi. I’m sorry to say this – while there’s a trigger warning here, there was no warning in the audio of the episode other than a vague reference to mental health, and Becca’s story is as close to a pro-ana story as one can get in a mainstream medium. It was a really unpleasant feeling for someone with eating disorders who doesn’t have a “good” reason for them.
I looove how big my brain has gotten since I started binging this podcast!!
Would you mind doing research on fibroids? There isn’t much research available on them but a large portion of the female population has them. The treatments are pretty interesting too! For example, you can use radio frequency to shrink them.
Having celiac is tough! It truly impacts all areas of your life – health, relationships, your social life, work, travel, etc. Thank you for bringing more awareness to celiac disease through your podcast!
Thank you for covering Celiac disease in this week’s episode. I was diagnosed in late 2020 after years of seemingly unrelated symptoms.
One thing I’d love for you to look into (maybe if you ever do episode updates), is the research in Australia on whether hookworms can cure Celiac disease. I just heard about it today and have yet to do my own deep dive.
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