We’ve covered measles, we’ve taken on rubella, and now we’re finishing up the classic MMR vaccine by exploring the other M: mumps. To some listeners, mumps may be a painful childhood memory while to others it’s just a letter in a vaccine they were too young to remember getting. But by the end of this episode, we promise that you’ll all be much more familiar with this strange little virus. How does the mumps virus make you sick and give you that classic swollen face look? What is so bad about the mumps that Maurice Hilleman decided to snag a mumps sample from his sick daughter to make a vaccine? Where do we stand with mumps today and what do declining vaccination rates have to do with those not-so-great numbers? Tune in to hear our take on all these questions and many more in this classic TPWKY episode.
| History | Biology |
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| Kenneth, F. Kiple. “The Cambridge world history of human disease.” Cambridge University Press (1993). | Rubin, S., Eckhaus, M., Rennick, L.J., Bamford, C.G. and Duprex, W.P., 2015. Molecular biology, pathogenesis and pathology of mumps virus. The Journal of pathology, 235(2), pp.242-252. |
| Afzal, M. A., et al. “The Jeryl Lynn vaccine strain of mumps virus is a mixture of two distinct isolates.” Journal of General Virology 74.5 (1993): 917-920. | World Health Organization, 2012. Mumps virus nomenclature update: 2012. Weekly Epidemiological Record= Relevé épidémiologique hebdomadaire, 87(22), pp.217-224. |
| Barskey, Albert E., John W. Glasser, and Charles W. LeBaron. “Mumps resurgences in the United States: a historical perspective on unexpected elements.” Vaccine 27.44 (2009): 6186-6195. | CDC. Mumps outbreaks. https://www.cdc.gov/mumps/outbreaks.html |
| Buynak, Eugene B., and Maurice R. Hilleman. “Live attenuated mumps virus vaccine. 1. Vaccine development.” Proceedings of the Society for Experimental Biology and Medicine 123.3 (1966): 768-775. | Marshall, H.S. and Plotkin, S., 2019. The changing epidemiology of mumps in a high vaccination era. The Lancet. Infectious diseases, 19(2), pp.118-119. |
| Drexler, Jan Felix, et al. “Bats host major mammalian paramyxoviruses.” Nature communications 3.1 (2012): 1-13. | Dayan, G.H., Quinlisk, M.P., Parker, A.A., Barskey, A.E., Harris, M.L., Schwartz, J.M.H., Hunt, K., Finley, C.G., Leschinsky, D.P., O’Keefe, A.L. and Clayton, J., 2008. Recent resurgence of mumps in the United States. New England Journal of Medicine, 358(15), pp.1580-1589. |
| Galazka, Artur M., Susan E. Robertson, and A. Kraigher. “Mumps and mumps vaccine: a global review.” Bulletin of the World Health Organization 77.1 (1999): 3. | Kitano, T., 2021. Close the gap for routine mumps vaccination in Japan. Human Vaccines & Immunotherapeutics, 17(1), pp.205-210. |
| Hamilton, Robert. “An account of a distemper, by the common people in england vulgarly called the mumps.” The London Medical Journal 11.Pt 2 (1790): 190. | Connell, A.R., Connell, J., Leahy, T.R. and Hassan, J., 2020. Mumps outbreaks in vaccinated populations—is it time to re-assess the clinical efficacy of vaccines?. Frontiers in Immunology, 11, p.2089. |
| Johnson, Claud D., and Ernest W. Goodpasture. “An investigation of the etiology of mumps.” The Journal of experimental medicine 59.1 (1934): 1. | |
| Pomeroy, Laura W., Ottar N. Bjørnstad, and Edward C. Holmes. “The evolutionary and epidemiological dynamics of the paramyxoviridae.” Journal of Molecular Evolution 66.2 (2008): 98-106. | |
| Tsoucalas, Gregory, et al. “The Thasian epidemic of mumps during the 5th century BC.” Infez Med 21.2 (2013): 149-50. | |
| Wolfe, Nathan D., Claire Panosian Dunavan, and Jared Diamond. “Origins of major human infectious diseases.” Nature 447.7142 (2007): 279-283. |
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