Almost everyone is familiar with diabetes mellitus in some way. Whether we know family or friends that have been diagnosed with the condition or we’re directly impacted ourselves, diabetes mellitus has become a household name. And this is perhaps not surprising given its extremely high prevalence – nearly 9% of adults around the globe are estimated to live with the disease. But although we may know someone with diabetes, how much do we know about diabetes itself? How does it work? Why does it cause the acute symptoms and long-term complications it does? Where does an infamous scientific rivalry fit into the story of diabetes? How long have humans been dealing with this disease, and how far has treatment come since the early days of diabetes? And importantly, how has our perception and portrayal of diabetes changed over the course of its history? In this episode, we seek to answer all these questions and many more about the globally-prevalent diabetes mellitus.
| History | Biology |
| Bliss, Michael. The discovery of insulin. University of Toronto Press, 2019. | Poretsky, L. ed., 2010. Principles of diabetes mellitus (Vol. 21). Springer Science & Business Media. |
| Tattersall, Robert. Diabetes: the biography. Oxford University Press, 2009. | Zaccardi, F., Webb, D.R., Yates, T. and Davies, M.J., 2016. Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective. Postgraduate medical journal, 92(1084), pp.63-69. |
| Tuchman, Arleen Marcia. Diabetes: A History of Race and Disease. United States. Yale University Press, 2020. | Oguntibeju, O.O., 2019. Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. International journal of physiology, pathophysiology and pharmacology, 11(3), p.45. |
| Ahmed, Awad M. “History of diabetes mellitus.” Saudi medical journal 23.4 (2002): 373-378. | Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K.B., Ostolaza, H. and Martín, C., 2020. Pathophysiology of type 2 diabetes mellitus. International journal of molecular sciences, 21(17), p.6275. |
| Karamanou, Marianna, et al. “Milestones in the history of diabetes mellitus: The main contributors.” World journal of diabetes 7.1 (2016): 1. | American Diabetes Association, 2018. Economic costs of diabetes in the US in 2017. Diabetes care, 41(5), pp.917-928. |
| Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A.A., Ogurtsova, K. and Shaw, J.E., 2019. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas. Diabetes research and clinical practice, 157, p.107843. | |
| Williams, R., Karuranga, S., Malanda, B., Saeedi, P., Basit, A., Besançon, S., Bommer, C., Esteghamati, A., Ogurtsova, K., Zhang, P. and Colagiuri, S., 2020. Global and regional estimates and projections of diabetes-related health expenditure: Results from the International Diabetes Federation Diabetes Atlas. Diabetes research and clinical practice, 162, p.108072. | |
| Bentsen, M.A., Rausch, D.M., Mirzadeh, Z., Muta, K., Scarlett, J.M., Brown, J.M., Herranz-Pérez, V., Baquero, A.F., Thompson, J., Alonge, K.M. and Faber, C.L., 2020. Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission. Nature communications, 11(1), pp.1-16. | |
| Brown, J.M., Scarlett, J.M., Matsen, M.E., Nguyen, H.T., Secher, A., Jorgensen, R., Morton, G.J. and Schwartz, M.W., 2019. The hypothalamic arcuate nucleus–median eminence is a target for sustained diabetes remission induced by fibroblast growth factor 1. Diabetes, 68(5), pp.1054-1061. |
Disclaimer: This post may contain affiliate links. If you buy something through one of these links, you won’t pay a penny more, but we’ll get a small commission which helps us keep things running. Thanks!
