What better time to explore the world of coronaviruses than amidst an outbreak of the 2019 novel coronavirus that brings to mind memories of SARS and MERS? On this very special episode of This Podcast Will Kill You, we’ll take you through what we know about this diverse group of viruses, from the mild strains constantly circulating to the epidemic ones that make headlines with their lethality. Want to know how exactly these royal viruses make you sick? Or what went on during the 2002-2003 SARS epidemic? Don’t worry – we’ve got you covered. And to help us get a grasp on the current 2019-nCoV outbreak that’s got the world’s attention, we’ve brought on four experts from Emory University to give us the lowdown: Dr. Colleen Kraft, Dr. G. Marshall Lyon, Dr. Aneesh Mehta, and Dr. Carlos del Rio.
*Please keep in mind, we recorded this episode on Sunday, Feb 2 and conducted the interviews between Jan 29 and 30, 2020. Since recording, the statistics on 2019-nCoV that we and our guests reported have changed as the epidemic continues to evolve. The figures are changing fast, but the basic info is still relevant.
- WHO 2019-nCoV website, especially the Situation Reports
- Map Dashboard of 2019-nCoV Cases by Johns Hopkins Center for Systems Science and Engineering
- CDC 2019-nCoV website
Expert Guests:
Colleen S. Kraft, MD, MSc
Associate Chief Medical Officer, Emory University Hospital
Twitter: @colleenkraftmd
Carlos del Rio, MD
Professor, Emory Vaccine Center
Professor and Chair, Hubert Department of Global Health, Rollins School of Public Health
Professor, Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine
Investigator, Emory Center for AIDS Research
Twitter: @CarlosdelRio7
Aneesh K. Mehta, M.D., FIDSA, FAST
Associate Professor of Medicine, Emory University School of Medicine
Chief of Infectious Diseases Services, Emory University Hospital
Twitter: @AneeshMehtaMD
G. Marshall Lyon, MD, MMSc
Professor of Medicine
Director of Transplant Infectious Diseases
Chair, Emory Institutional Biosafety Committee
Chair, Emory Research Health & Safety Committee
Emory University School of Medicine
Twitter: @GMLyon3
Episode 43 M-m-m-my Coronaviruses transcript (pdf)
| History | Biology |
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Zhao et al. Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov bioRxiv 2020.01.26.919985; doi: https://doi.org/10.1101/2020.01.26.919985 (Pre-print, not peer-reviewed) |
| Lu, Guangwen, and Di Liu. “SARS-like virus in the Middle East: a truly bat-related coronavirus causing human diseases.” Protein & cell 3.11 (2012): 803. | |
| Lu, R., et al. 2020. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. | |
| Mackay, Ian M., and Katherine E. Arden. “MERS coronavirus: diagnostics, epidemiology and transmission.” Virology journal 12.1 (2015): 222. | |
| Shehata, Mahmoud M., et al. “Middle East respiratory syndrome coronavirus: a comprehensive review.” Frontiers of medicine 10.2 (2016): 120-136. | |
| Zhou, Peng, et al. “Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin.” bioRxiv (2020). ***Draft paper, not yet peer-reviewed*** | |
| http://www.emro.who.int/health-topics/mers-cov/mers-outbreaks.html | |
| https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/ |
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