Our first vector-borne disease episode of season 3 and our first mosquito-borne pathogen in quite some time, dengue virus proves itself to be more than a worthy topic (and quite a formidable adversary in terms of public health). This week we are joined by Dr. Alex Trillo who drops some firsthand knowledge on the excruciating symptoms that give dengue its colloquial name “breakbone fever”, and then we trace the virus’s path from its evolutionary origins in ancient forests to the inevitable emergence of dengue hemorrhagic fever following modern war. We round it all out with some truly horrifying stats on the prevalence of dengue today as well as some promising research on reducing the prevalence of dengue tomorrow.
To find out more about Alex’s incredibly cool research, check out her website at www.alextrillo.com and follow her on Twitter at @Trillo_PA.
| History | Biology |
| Patterson, Gordon. The mosquito crusades: a history of the American anti-mosquito movement from the Reed commission to the first Earth Day. Rutgers University Press, 2009. | Simmons, Cameron P., et al. “Dengue.” New England Journal of Medicine 366.15 (2012): 1423-1432. |
| Kenneth, F. Kiple. “The Cambridge world history of human disease.” CUP, Cambridge (1993): 871. | Halstead, Scott B. “Pathogenesis of dengue: dawn of a new era.” F1000Research 4 (2015) |
| Gubler, Duane J., et al., eds. Dengue and dengue hemorrhagic fever. CABI, 2014. | Gubler, Duane J., et al., eds. Dengue and dengue hemorrhagic fever. CABI, 2014 |
| Dick, Olivia Brathwaite, et al. “The history of dengue outbreaks in the Americas.” The American journal of tropical medicine and hygiene 87.4 (2012): 584-593. | Rothman, Alan L., ed. Dengue Virus. Springer, 2010 |
| Ehrenkranz, N. Joel, et al. “Pandemic dengue in Caribbean countries and the southern United States—past, present and potential problems.” New England Journal of Medicine 285.26 (1971): 1460-1469. | Bhatt, Samir, et al. “The global distribution and burden of dengue.” Nature 496.7446 (2013): 504 |
| Rush, Benjamin. “An account of the bilious remitting fever: As it appeared in philadelphia, in the summer and autumn of the year 1780.” The American Journal of Medicine 11.5 (1951): 546-550. | Schmidt, Tom L., et al. “Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes aegypti.” PLoS biology 15.5 (2017): e2001894 |
| Salles, Tiago Souza, et al. “History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: a review.” Parasites & vectors 11.1 (2018): 264. | O’Neill, Scott L., et al. “Scaled deployment of Wolbachia to protect the community from dengue and other Aedes transmitted arboviruses.” Gates open research 2 (2018). |
| Villar, Luis, et al. “Efficacy of a tetravalent dengcue vaccine in children in Latin America.” New England Journal of Medicine 372.2 (2015): 113-123 | |
| Hadinegoro, Sri Rezeki, et al. “Efficacy and long-term safety of a dengue vaccine in regions of endemic disease.” New England Journal of Medicine 373.13 (2015): 1195-1206 | |
| https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue |
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